Compósito de montimorilonita-celulose bacteriana como um novo sistema curativo para lesões por pressão

Abstract

ABSTRACT

The main objective of this study was to investigate the effects and the underlying mechanisms of action of BC hydrogel incorporated into MMT (BCH-MMT) for skin wound healing using mice pressure injury model. Komagataeibacter hansenii was used to obtain the BC composites, which were incorporated with MMT and characterized through Fourier transform infrared spectroscopy (FT-IR), and Scanning Electron Microscopy (SEM). Pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice. BC and BC+MMT showed a typical FTIR spectrum of cellulosic substrates with strong bands at around 3344, 2920, 1637, and 1041 cm-1, and microparticles of MMT showed disperse uniformly throughout BC. To our knowledge, our findings showed for the first time that animals treated with modified BCH-MMT showed significant healing of pressure ulcers with tissue regeneration, reduced area of redness, spontaneous hyperalgesia, complete re-epithelialization of the epidermis and inhibited inflammatory cells similarly to Dersani® used as a positive control. Altogether, these findings suggest that a modified BCH-MMT hydrogel film have the potential to be a novel dressing material for pressure injury and a scaffold for skin tissue engineering.