Cirurgia bariátrica: efeitos sobre o estado antioxidante e estresse oxidativo

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Cirurgia bariátrica: efeitos sobre o estado antioxidante e estresse oxidativo

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Title: Cirurgia bariátrica: efeitos sobre o estado antioxidante e estresse oxidativo
Author: Boesing, Fernanda
Abstract: Oxidative stress is associated with obesity. Although bariatric surgery is the predominant treatment for individuals with morbid obesity, implications of the surgical weight loss to the antioxidant balance and oxidative stress are not clarified yet. The objective of this study was to evaluate the effect of surgical weight loss on caloric ingestion, sanguineous levels of vitamin C, â-carotene, vitamin E, reduced glutathione (GSH), catalase (CAT) and myeloperoxidase (MPO) activities and thiobarbituric acid-reactive substances (TBARS). A clinical study was realized in the University Hospital of the Federal University of Santa Catarina with a control group (GC) and a bariatric group (GB), both with 20 individuals. The mean age was 38±11 years in both groups and Body Mass Index (BMI) was 22,4±2,4 kg/m2 and 48±8,7 kg/m2, respectively. The GC was evaluated in only one moment and GB was evaluated before surgery (baseline), 3 and 6 months after Roux-en-Y gastric bypass. The caloric ingestion (3119±799 to 1164±429 calories/day) and MPO (384,18±18,20 to 32,79±69,20 mU/mL) significantly decreased in six after surgical months in relation to baseline. Moreover, the study showed an increase in vitamin C (0,46±0,14 to 0,76±0,35 mg/dL), â-carotene (0,51±0,53 to 1,72±0,23 ìM), vitamin E - corrected ratio - (0,006±0,003 to 0,013±0,007 ìmol/ mg), CAT (15,98±6,41 to 24,86±9,78 mmol H2O2/ min/mL) and TBARS (14,59±2,42 to 26,89±6,70 nmol/ mL) in six after surgical months. These results had been similar to the GC. The significant correlations in GB were demonstrated between BMI and vitamin C, â-carotene, TBARS and MPO (rho= -0,269; -0,492; -0,346 e 0,576, respectively). Concluding, this study evidenced weight reduction and caloric ingestion decrease after surgery. It presented an improvement in vitamin E, vitamin C and â-carotene levels, a reduction in MPO levels and an increase in CAT and TBARS levels after surgical intervention.
Description: Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pos-Graduação em Nutrição.
Date: 2008

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